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Type of Document	Dissertation
Author	Fischer, Glenn Albert
URN	etd-12102003-111246
Persistent URL	http://resolver.caltech.edu/CaltechETD:etd-12102003-111246
Title	Genetic and biochemical studies of the cystine-methionine series of mutants in Neurospora crassa
Degree	PhD
Option	Biology
Advisory Committee	Advisor Name Title N.H. Horowitz Committee Chair
Keywords	None
Date of Defense	1954-01-01
Availability	unrestricted
Abstract NOTE: Text or symbols not renderale in plain ASCII are indicated by [...]. Abstract is included in .pdf document. 1. The following enzyme activities were studied in extracts of wild type and mutant Neurospora: [...]. Activity 2 was shown to be absent in a homocysteineless mutant and activity 3 was shown to be absent in a cystathionineless mutant. It was found that a suppressor, obtained by Giles, which causes these mutants to grow on minimal, returns enzyme activity to the mutants. Each activity is shown to be catalyzed by a different enzyme. 2. Evidence is presented which indicates that a Neurospora cystathionineless mutant can synthesize cystathionine from methionine without the intervention of cysteine. 3. Mutants which are blocked between thiosulfate and cysteine are shown to grow on elemental sulfur and H[subscript 2]S.
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