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Type of Document	Dissertation
Author	Vannier, Wilton Emile
URN	etd-01262006-102957
Persistent URL	http://resolver.caltech.edu/CaltechETD:etd-01262006-102957
Title	I. House dust allergens. II. Experiments on the distensibility of the excised rabbit bladder
Degree	PhD
Option	Chemistry
Advisory Committee	Advisor Name Title Dan Hampton Campbell Committee Chair
Keywords	none
Date of Defense	1958-01-01
Availability	unrestricted
Abstract Part I: The problem of the nature of house dust allergens has been investigated by studying the chemical and physical properties of active fractions of aqueous dust extracts. The fractions consisted largely of a heterogeneous mixture of acidic polysaccharides and in lesser amounts a polypeptide component (2-30%), probably linked to the polysaccharides. The polysaccharides contained uronic acid (probably mostly glucuronic acid), D-glucose, D-mannose, D-galactose and L-rhamnose and lesser amounts of a number of pentoses. Nitrogen free active polysaccharide fractions have not been obtained. The most purified active fraction contained 0.4% nitrogen. The relation between the chemical and physical properties of the fractions and current ideas of the origin of the dust allergens was discussed. Part II: Rabbit bladder stretching curves under constant pressure have been studied. A method, involving the use of eserine and acetylcholine, has been found to restretch the same bladder and obtain reproducible curves. The effect of temperature and epinephrine upon the bladder stretching curves was investigated.
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